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The Navigation Guide: Selected Milestones University of California, San Francisco Program on Reproductive Health and the Environment August 2009 to February 2014

August 2009
Navigating the Scientific Evidence to Improve Prevention Workshop
Two-day meeting of collaborators held to develop a methodology for the efficient evaluation of reproductive environmental health science to catalyze preventative action in medical, public health and policy arenas.

November 2009
Collaborative on Health and the Environment (CHE) Partnership Call
Navigating the Scientific Evidence to Ensure Prevention. Available at:

January 2010
European Environmental Agency
Navigation Guide meeting convened by collaborator David Gee of the European Environmental Agency in Copenhagen with colleagues from the European Centers for Disease Control and the Institute of Community Medicine, University of Tromsø, Norway who are also engaged in developing weight of the evidence methodologies for infectious disease and complementary medicine specialties.

February 2010
Green Choices
Presentation about the Navigation Guide to participants at Green Choices retreat. Green Choices is a national coalition led by Planned Parenthood Federation of America (PPFA) that brings together reproductive and environmental health scientists, clinicians and advocates towards common goals.

March 2010
San Francisco Medical Society
Published The Navigation Guide: An Evidence-Based Tool to Bridge the Gap Between Clinical Practice and Environmental Health Science in the journal of the San Francisco Medical Society
Available at:

April 2010
National Institute of Environmental Health Sciences
Conversation and collaboration initiated with Kristina A. Thayer, PhD, Director of the National Toxicology Program Office of Health Assessment and Translation on the development of weight of evidence methodologies.

May 2010
American Congress of Obstetricians and Gynecologists (ACOG)
Met with ACOG’s national leadership (Hal Lawrence, MD) including discussion of the applicability of the Navigation Guide to clinical practice.

August 2010
Environmental Health Perspectives
Woodruff TJ, Sutton P. Pulling back the curtain: improving reviews in environmental health. Environ Health Perspect. 2010 Aug;118(8):a326-7. Available at:

August/September 2010
Agency for Healthcare Research Quality (AHRQ)
Met with Jean R. Slutsky, P.A., M.S.P.H., Director, Center for Outcomes and Evidence at AHRQ by phone to discuss the Navigation Guide followed by attendance at AHRQ’s annual conference in Bethesda.

September 2010
Santa Clara County Medical Society
Published The Navigation Guide: An Evidence-Based Tool to Bridge the Gap Between Clinical Practice and Environmental Health Science in the journal of the Santa Clara County Medical Society.

September 2010
California Preconception Care Council
The mission of the Preconception Health Council of California is to engage individuals, communities, health care organizations and policymakers to optimize the health and well-being of women and their partners, leading to healthier infants and families. The Council includes public and private providers from various health and social service agencies. Presentation to the Council leaders on the Navigation Guide and other aspects of the science related to reproductive health and the environment.

November 2010
Current Opinion in Obstetrics and Gynecology
Published article about advances in reproductive environmental health including discussion of the Navigation Guide. Sutton P, Giudice LC, Woodruff TJ. Reproductive environmental health. Curr Opin Obstet Gynecol. 2010 Dec;22(6):517-24. Review.

April 2011
Clean Med
Presentation on Navigation Guide to participants at the Research Exchange on Advancing Patient, Worker and Environmental Safety & Sustainability in the Health Care Sector.

May 2011
Publication of the method and presentation at the symposia that launched the first issue of Health Affairs to address environmental health, WA DC. Woodruff TJ, Sutton P; Navigation Guide Work Group. An evidence-based medicine methodology to bridge the gap between clinical and environmental health sciences. Health Aff (Millwood). 2011 May;30(5):931-7.
Download the article at no cost at:

June 2011
Collaborative on Health and the Environment (CHE) Partnership Call
Navigating the Science: Ensuring Research Quality. Available at:

July 2011
U.S. Environmental Protection Agency
Leadership of the American Congress of Obstetricians & Gynecologists (ACOG) (Jerry Joseph, MD, ACOG’s Executive Vice President for Practice) and ACOG District IX (Jeanne Conry, MD, PhD) met with Peter Grevatt, Director of the Office of Children’s Health Protection and Environmental Education.

August 2011
U.S. Environmental Protection Agency/National Toxicology Program
Initiated work with USEPA and National Toxicology Program scientists to apply the Navigation Guide and related weight of evidence methods to one or more case studies.

August 2011
Navigation Guide Working Group Inaugural Meeting
U.S. Environmental Protection Agency - Webinar for USEPA scientists on Navigation Guide

September 2011
Presentation about the Navigation Guide at the Association of Reproductive Health Professionals annual meeting, Las Vegas, NV.

December 2011
Sutton P, Woodruff TJ, Vogel S, Bero LA. Conrad and Becker's "10 Criteria"fall short of addressing conflicts of interest in chemical safety studies. Environ Health Perspect. 2011 Dec;119(12):A506-7
Presentation on the Navigation Guide to scientists at the Agency for Toxic Substances and Disease Registry

January 2012
Presentation on the Navigation Guide at the meeting of the western National Institute of Environmental Health Services and USEPA Children’s Centers

March 2012
Publication of article in the American Journal of Obstetrics and Gynecology about role of obstetricians in preventing environmental exposures including reference to development of clinical guidelines using the Navigation Guide.  Sutton P, Woodruff TJ, Perron J, Stotland N, Conry JA, Miller MD, Giudice LC.  Toxic environmental chemicals: the role of reproductive health professionals in preventing harmful exposures. Am J Obstet Gynecol. 2012 Sep;207(3):164-73. doi: 10.1016/j.ajog.2012.01.034. Epub 2012 Mar 8. PubMed PMID: 22405527. http://www-ncbi-nlm-nih-gov.ucsf.idm.oclc.org/pubmed/22405527

Presentation to the USEPA Children’s Health Protection Advisory Committee about the Navigation Guide (3/28/12)

Meeting with scientists at the California Environmental Protection Agency about the Navigation Guide (3/27/12)

Two-day meeting of the Navigation Guide Working Group at UCSF’s Parnassus Campus (March 9-10, SF CA)

May 2012
US Environmental Protection Agency Test-Driving the Navigation Guide: PFOA and Reduced Fetal Growth (Erica Koustas and Juleen Lam) (May 30, WA DC)

June 2012
Approaches to Weight Of Evidence in Chemical Toxicity Assessment, meeting organized by Ake Bergman, Stockholm University. The Navigation Guide: A Systematic and Transparent Method to Evaluate Environmental Health Science (Tracey Woodruff)
Navigation Guide Work Group Webinar (June 28)

July 2012
Triservice Environmental Risk Assessment Workgroup (TSERAWG). This workgroup is made up of US Department of Defense risk assessors, biologists and toxicologists who meet a few times a year to discuss concerns (emerging contaminants, legacy compounds, new risk approaches). Test-Driving the Navigation Guide: PFOA and Reduced Fetal Growth (Erica Koustas and Juleen Lam) (July 10 Aberdeen Proving Grounds, MD)

August 2012
NTP Board of Scientific Counselors Working Group on Reaching Evidence Assessment Conclusions (August 28, Research Triangle Park, North Carolina)

International Society for Environmental Epidemiology - Navigation Guide: A Systematic Methodology to Sort the Scientific Evidence Linking Environmental Exposures to Adverse Health Outcomes (Tracey Woodruff, Erica Koustas and Juleen Lam) (August 29 Columbia, SC)

California Environmental Protection Agency. Presentation on the Navigation Guide Systematic  Review  Methodology,  Oakland, CA

September 2012
Improving the Use of Science in Administrative Process. A Workshop Under the Auspices of The National Academy of Sciences' Committee on Science, Technology and Law in Collaboration with The Administrative Conference of the United States (Tracey Woodruff)
Navigation Guide Work Group Meeting (Webinar) (September 20)

January 2013
Navigation Guide Work Group Meeting (Webinar) (January 15)

February 2013
U.S. Environmental Protection Agency. The Navigation Guide. Meeting and presentation to Kenneth Oden, Director, National Center for Environmental Assessment and John Vandenberg, National Program Director Human Health Risk Assessment Research Program and other EPA leadership.  (Tracey Woodruff, Patrice Sutton, Erica Koustas, Juleen Lam) (February 20 WA DC)

Federal Summit on Evaluating and Synthesizing Evidence: Applying Systematic Review to Questions of the Health Effects of Chemical Exposures. The Navigation Guide Evidence-Based Medicine Meets Environmental Health: PFOA and Fetal Growth (Erica Koustas and Juleen Lam) (February 27-28 Research Triangle Park, NC)

March 2013
2nd International Symposium on the Systematic Reviews of Animal Data, The Navigation Guide: integrating meta-analysis to weight of evidence assessments in reproductive toxicology (Tracey Woodruff) (March 7-8 Edinburgh, Scotland)
Society for Toxicology - Risk communication and decision tools for children’s health protection. (Tracey Woodruff); The Navigation Guide as an Evidence-Based Medicine Methodology to Evaluate Human Health Effects of Environmental Chemicals: Perfluorooctanoic Acid (PFOA) and Fetal Growth (Erica Koustas) (March 10-14 San Antonio TX)
National Academy of Sciences, Weight of Evidence National Research Council  Committee to Review the IRIS Process  Putting the Pieces Together: A Case Study (Tracey Woodruff) (March 28, WA DC)

Sutton P, Woodruff TJ. Risk communication and decision tools for children's health protection. Birth Defects Res C Embryo Today. 2013 Mar;99(1):45-9. doi: 10.1002/bdrc.21029. Review. Erratum in: Birth Defects Res C Embryo Today. 2013 Jun;99(2):147. PubMed PMID: 23723171. http://www-ncbi-nlm-nih-gov.ucsf.idm.oclc.org/pubmed/23723171

May 2013
Navigation Guide Work Group Meeting (Webinar) (May 14)

June 2013
Submitted written comments to National Toxicology Program on its draft OHAT approach for systematic review and evidence integration for literature-based health assessments. Our comments are at: http://ntp.niehs.nih.gov/NTP/OHAT/EvaluationProcess/PublicComm/Woodruff20130611_508.pdf
All of the public comments can be found at: http://ntp.niehs.nih.gov/?objectid=922A59D1-BD4B-3D2B-077DC835C97F7828

July 2013
Canadian Partnership for Children's Health and Environment (CPCHE). The Navigation Guide:  A Systematic and Transparent Method to Evaluate Environmental Health Science. (July 22, Webinar).

International Society of Environmental Epidemiology. The Navigation Guide - Evidence-Based Medicine Meets Environmental Health: PFOA and Fetal Growth. (Basal, Switzerland, August 20).

August 2013
EPA Workshop: Applying Systematic Review to Assessments of Health Effects
of Chemical Exposures http://www.epa.gov/iris/irisworkshops/systematicreview/wrk_agenda.htm (August 26, Washington, DC)  

September 2013
Navigation Guide Work Group Meeting (September 3rd)

Mid-Atlantic Center for Children's Health and the Environment Children's National Medical Center Conference on Environmental Health for Obstetricians and Gynecologists. (Arlington, VA, September 20).

Featured publication article in Environmental Health Perspectives
Krauth D, Woodruff TJ, Bero L. Instruments for Assessing Risk of Bias and Other Methodological Criteria of Published Animal Studies: A Systematic Review.Environ Health Perspect. 2013 Jun 14. [Epub ahead of print]

October 2013
Presentation to Institute of Medicine at Annual Meeting (October 21, Washington DC. )

November 2013
Vesterinen HM, Johnson PI, Koustas E, Lam J, Sutton P, Woodruff TJ. In Support
of EHP's Proposal to Adopt the ARRIVE Guidelines. Environ Health Perspect. 2013
Nov-Dec;121(11-12):A325. doi: 10.1289/ehp.1307775. PubMed PMID: 24284027; PubMed
Central PMCID: PMC3855525. http://ehp.niehs.nih.gov.ucsf.idm.oclc.org/1307775/

10th Women’s Health Congress. New Paradigms in Evaluating Scientific Evidence for Environment and Reproduction. World Health Organization. (Geneva, Switzerland, January 10).

January 2014
Submitted written recommendations to Cal-EPA for summarizing data from epidemiological and toxicological studies specifically commenting on the example tables that were presented to the Developmental and Reproductive Toxicant Identification (DART) Committee for discussion on December 4, 2013 and posted on the Office for Environmental Health Hazard Assessment website for public comment. http://oehha.ca.gov/prop65/CRNR_notices/pdf_zip/013014UCSFCommentsDART.pdf

February 2014
American Association for the Advancement of Science. Lifecourse Approaches for Ensuring Children's Environmental Health Protection. (Chicago, IL, February 14).

Green Science Policy Institute. Navigating the Science on Flame Retardants (Johnson). (February 14, Berkeley, CA).

Navigation Guide Work Group Meeting (February 12).

Making the Connection.  Wisconsin Environmental Health Network. (Madison, WI February 28).

Navigation Guide Strategy

Learn more about the strategy behind the Navigation Guide.

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